Mouse P4htm activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	P4htm
Locus ID	74443
Kit Components	GA209889G1, P4htm gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209889G2, P4htm gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209889G3, P4htm gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_028944, NM_001357465, NR_151688
Synonyms	4933406E20Rik; AI853847; BB128974; Ph-4
Summary	Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.[UniProtKB/Swiss-Prot Function]

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