Mouse Kdm5b activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Kdm5b
Locus ID	75605
Kit Components	GA210280G1, Kdm5b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210280G2, Kdm5b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210280G3, Kdm5b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_152895
Synonyms	2010009J12Rik; 2210016I17Rik; AW556288; D1Ertd202e; Jarid1b; mKIAA4034; PLU-1; Plu1; PUT1; Rb-Bp2
Summary	This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016]

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