Mouse Dock11 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dock11
Locus ID	75974
Kit Components	GA210412G1, Dock11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210412G2, Dock11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210412G3, Dock11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001009947, NM_177745
Synonyms	5033414A21Rik; 8030476J24; sph238; Zizimin2
Summary	Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:15710388, PubMed:16968698, PubMed:25851601). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (PubMed:25729399). Facilitates filopodia formation through the activation of CDC42 (PubMed:22494997).[UniProtKB/Swiss-Prot Function]

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