Mouse Arhgap15 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Arhgap15
Locus ID	76117
Kit Components	GA210435G1, Arhgap15 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210435G2, Arhgap15 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210435G3, Arhgap15 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001025377, NM_001301831, NM_001301832, NM_153820
Synonyms	5830480G12Rik
Summary	The protein encoded by this gene is a RAC GTPase-activating protein that is regulated through its PH domain and by recruitment to the membrane. The protein accelerates hydrolysis of guanosine triphosphate to guanosine diphosphate to repress Rac activity. Knock-out of Arhgap15 function demonstrates that this gene is required to regulate multiple functions in macrophages and neutrophils. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

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