Mouse Adhfe1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Adhfe1
Locus ID	76187
Kit Components	GA210452G1, Adhfe1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210452G2, Adhfe1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210452G3, Adhfe1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_175236, NR_027664, NM_001357376, NM_001357377, NM_001357378
Synonyms	6330565B14Rik; Adh8; AI043035
Summary	Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity).[UniProtKB/Swiss-Prot Function]

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