Mouse Mib2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mib2
Locus ID	76580
Kit Components	GA210548G1, Mib2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210548G2, Mib2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210548G3, Mib2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001256107, NM_001256108, NM_001256110, NM_145124, NM_001369161, NM_001369162, NM_001369163, NM_001369164, NM_001369165, NM_001369166, NM_001369167, NM_001369168
Synonyms	2210008I11Rik; skd; Zzank1
Summary	E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.[UniProtKB/Swiss-Prot Function]

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