Mouse Prdm8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Prdm8
Locus ID	77630
Kit Components	GA210790G1, Prdm8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210790G2, Prdm8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210790G3, Prdm8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_029947
Synonyms	4930565F05Rik; PFM5
Summary	Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (PubMed:19646955). Histone methyltransferase activity has not been confirmed in other species. Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (PubMed:19646955). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (PubMed:22284184). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (PubMed:26023183).[UniProtKB/Swiss-Prot Function]

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