Mouse Rnase6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rnase6
Locus ID	78416
Kit Components	GA210957G1, Rnase6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210957G2, Rnase6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210957G3, Rnase6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_030098, NM_001360117, NR_153407
Synonyms	9530043P15Rik; BB119466
Summary	Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:15693621). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:15693621, PubMed:25075772). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (By similarity). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (By similarity).[UniProtKB/Swiss-Prot Function]

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