Mouse Wwox activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Wwox
Locus ID	80707
Kit Components	GA211121G1, Wwox gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211121G2, Wwox gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211121G3, Wwox gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_019573
Synonyms	5330426P09Rik; 9030416C10Rik; WOX1
Summary	Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (By similarity). May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development.[UniProtKB/Swiss-Prot Function]

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