Mouse Tbl1xr1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tbl1xr1
Locus ID	81004
Kit Components	GA211175G1, Tbl1xr1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211175G2, Tbl1xr1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211175G3, Tbl1xr1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_030732
Synonyms	8030499H02Rik; A630076E03Rik; AW539987; C21; C230089I12Rik; DC42; Ira1; TBLR1
Summary	F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity).[UniProtKB/Swiss-Prot Function]

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