Mouse Vangl2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Vangl2
Locus ID	93840
Kit Components	GA211362G1, Vangl2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211362G2, Vangl2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211362G3, Vangl2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_033509
Synonyms	C530001F03Rik; loop-tail; Lootl; Lp; Lpp1; Ltap; ska17; ska; stbm; strabismus; Vang1l2
Summary	Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (PubMed:16495441).[UniProtKB/Swiss-Prot Function]

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