Mouse Trim6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Trim6
Locus ID	94088
Kit Components	GA211404G1, Trim6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211404G2, Trim6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211404G3, Trim6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001013616
Synonyms	C430046K18Rik; D7Ertd684e
Summary	E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (PubMed:22328504). Involved in the synthesis of unanchored K48-linked polyubiquitin chains which interact with and activate the serine/threonine kinase IKBKE, leading to phosphorylation of STAT1 and stimulation of an antiviral response (PubMed:24882218).[UniProtKB/Swiss-Prot Function]

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