Mouse Dock2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dock2
Locus ID	94176
Kit Components	GA211415G1, Dock2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211415G2, Dock2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211415G3, Dock2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_033374
Synonyms	AI662014; AW122239; CED-5; Hch; MBC
Summary	Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.[UniProtKB/Swiss-Prot Function]

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