Mouse Zfp423 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zfp423
Locus ID	94187
Kit Components	GA211421G1, Zfp423 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211421G2, Zfp423 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211421G3, Zfp423 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001310520, NM_033327
Synonyms	ataxia1; Ebfaz; mKIAA0760; nur12; Roaz; Zfp104; Znf423
Summary	Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.[UniProtKB/Swiss-Prot Function]

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