Mouse Cmtm4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cmtm4
Locus ID	97487
Kit Components	GA211480G1, Cmtm4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211480G2, Cmtm4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211480G3, Cmtm4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_153582
Synonyms	Cklfsf4; D19397; ENSMUSG00000051554; Gm9853
Summary	Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.[UniProtKB/Swiss-Prot Function]

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