Mouse Lrrc19 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Lrrc19
Locus ID	100061
Kit Components	GA211577G1, Lrrc19 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211577G2, Lrrc19 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211577G3, Lrrc19 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_175305, NM_001356281
Synonyms	9130022A01Rik; AI314124; AL022954; AW261791
Summary	Pathogen-recognition receptor which mediates the activation of TRAF2- and TRAF6 NF-kappa-B signaling pathways and induces the expression of proinflammatory cytokines (PubMed:26776522, PubMed:19679103, PubMed:25026888). In kidney, prevents infection by uropathogenic bacteria by inducing the production of cytokines, chemokines and antimicrobial substances (PubMed:25026888). In gut, involved in host-microbiota interactions, plays a critical role in promoting the recruitment of immune cells and intestinal inflammation (PubMed:26776522).[UniProtKB/Swiss-Prot Function]

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