Mouse Ccp110 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ccp110
Locus ID	101565
Kit Components	GA211657G1, Ccp110 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211657G2, Ccp110 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211657G3, Ccp110 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_182995, NM_001360793, NM_001360794
Synonyms	6330503K22Rik; AA415922; AI427129; AW557948; CP110
Summary	Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:23141541). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (PubMed:26965371). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (By similarity).[UniProtKB/Swiss-Prot Function]

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