Mouse Efl1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Efl1
Locus ID	101592
Kit Components	GA211658G1, Efl1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211658G2, Efl1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211658G3, Efl1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001159672, NM_175317
Synonyms	4932434J20Rik; 6030468D11Rik; AI451340; AU019507; AU022896; D7Ertd791e; Eftud1
Summary	Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits (By similarity).[UniProtKB/Swiss-Prot Function]

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