Mouse Ezhip activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ezhip
Locus ID	102991
Kit Components	GA211726G1, Ezhip gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211726G2, Ezhip gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211726G3, Ezhip gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001033211, NM_001166433
Synonyms	AU023811
Summary	Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation at 'Lys-27' (H3K27me3) (PubMed:31086175). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (By similarity). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (PubMed:31451685).[UniProtKB/Swiss-Prot Function]

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