Mouse Scrib activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Scrib
Locus ID	105782
Kit Components	GA211892G1, Scrib gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211892G2, Scrib gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211892G3, Scrib gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001310542, NM_001310543, NM_134089
Synonyms	AI118201; Crc; CRIB; mKIAA0147; Scrb1; SCRIB1; vartul
Summary	Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.[UniProtKB/Swiss-Prot Function]

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