Mouse Mtbp activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mtbp
Locus ID	105837
Kit Components	GA211898G1, Mtbp gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211898G2, Mtbp gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211898G3, Mtbp gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001168250, NM_134092
Synonyms	AI429604; MDM2BP
Summary	May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells.[UniProtKB/Swiss-Prot Function]

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