Mouse Mpig6b activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mpig6b
Locus ID	106722
Kit Components	GA211947G1, Mpig6b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211947G2, Mpig6b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211947G3, Mpig6b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001033221, NM_001191012
Synonyms	AU023871; C6orf25; Ng31
Summary	Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:23112346). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (By similarity). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:23112346). Appears to operate in a calcium-independent manner (By similarity).[UniProtKB/Swiss-Prot Function]

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