Mouse Lpxn activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Lpxn
Locus ID	107321
Kit Components	GA211983G1, Lpxn gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211983G2, Lpxn gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211983G3, Lpxn gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_134152, NM_001361971
Synonyms	4933402K05Rik; A530083L21Rik; AV278559; LDPL
Summary	Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.[UniProtKB/Swiss-Prot Function]

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