Mouse Il1rl2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Il1rl2
Locus ID	107527
Kit Components	GA212005G1, Il1rl2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212005G2, Il1rl2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212005G3, Il1rl2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_133193, NM_001356478
Synonyms	AI481289; AW551444; IL-1Rrp2
Summary	Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.[UniProtKB/Swiss-Prot Function]

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