Mouse Cdc20 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Cdc20
Locus ID	107995
Kit Components	GA212058G1, Cdc20 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212058G2, Cdc20 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212058G3, Cdc20 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_023223
Synonyms	2310042N09Rik; C87100; p55CDC
Summary	Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.[UniProtKB/Swiss-Prot Function]

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