Mouse Ccdc88a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ccdc88a
Locus ID	108686
Kit Components	GA212128G1, Ccdc88a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212128G2, Ccdc88a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212128G3, Ccdc88a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_176841, NM_001363368, NM_001363369
Synonyms	A430106J12Rik; AI848406; Ape; C130096N06Rik; C330012F17Rik; D130005J21Rik; Girdin; Giv
Summary	Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (PubMed:19778506). Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself (PubMed:15753085). Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (PubMed:15753085). Essential for the integrity of the actin cytoskeleton and for cell migration (By similarity). Required for formation of actin stress fibers and lamellipodia (By similarity). May be involved in membrane sorting in the early endosome (By similarity). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein Crocc/Rootletin (By similarity).[UniProtKB/Swiss-Prot Function]

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