Mouse Orai1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Orai1
Locus ID	109305
Kit Components	GA212221G1, Orai1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212221G2, Orai1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212221G3, Orai1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_175423
Synonyms	D730049H07Rik; orai-1; Tmem142a
Summary	Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.[UniProtKB/Swiss-Prot Function]

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