Mouse Tmbim6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tmbim6
Locus ID	110213
Kit Components	GA212298G1, Tmbim6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212298G2, Tmbim6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212298G3, Tmbim6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001171034, NM_001171035, NM_001171036, NM_026669
Synonyms	5031406P05Rik; Bi1; Tegt
Summary	Suppressor of apoptosis (By similarity). Modulates unfolded protein response signaling (By similarity). Modulates ER calcium homeostasis by acting as a calcium-leak channel (By similarity). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (PubMed:21926971).[UniProtKB/Swiss-Prot Function]

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