Mouse Adarb1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Adarb1
Locus ID	110532
Kit Components	GA212323G1, Adarb1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212323G2, Adarb1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212323G3, Adarb1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001024837, NM_001024839, NM_001024840, NM_130895, NR_004429, NR_021486
Synonyms	1700057H01Rik; Adar2; AW124433; AW558573; BB220382; D10Bwg0447e; Red1
Summary	This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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