Mouse Ivns1abp activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ivns1abp
Locus ID	117198
Kit Components	GA212482G1, Ivns1abp gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212482G2, Ivns1abp gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212482G3, Ivns1abp gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001039511, NM_001039512, NM_054102, NM_001359262, NM_001359263, NM_028582
Synonyms	1190004M08Rik; 1700126I16Rik; AA960440; HSPC068; mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP
Summary	Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (PubMed:12213805, PubMed:16317045). Protects cells from cell death induced by actin destabilization (PubMed:16952015). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (By similarity). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (By similarity). Inhibits pre-mRNA splicing (in vitro) (By similarity).[UniProtKB/Swiss-Prot Function]

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