Mouse Tlr3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tlr3
Locus ID	142980
Kit Components	GA212551G1, Tlr3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212551G2, Tlr3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212551G3, Tlr3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_126166, NM_001357316, NM_001357317
Synonyms	AI957183
Summary	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity).[UniProtKB/Swiss-Prot Function]

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