Mouse Card14 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Card14
Locus ID	170720
Kit Components	GA212573G1, Card14 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212573G2, Card14 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212573G3, Card14 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_130886
Synonyms	Bimp2; CARMA2
Summary	Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.[UniProtKB/Swiss-Prot Function]

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