Mouse Mbnl3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mbnl3
Locus ID	171170
Kit Components	GA212634G1, Mbnl3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212634G2, Mbnl3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212634G3, Mbnl3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001310515, NM_134163
Synonyms	A530038J18Rik; AI661274; CHCR; E430034C16Rik; MBLX; MBLX39; MBXL
Summary	Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins (By similarity). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.[UniProtKB/Swiss-Prot Function]

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