Mouse Shkbp1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Shkbp1
Locus ID	192192
Kit Components	GA212705G1, Shkbp1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212705G2, Shkbp1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212705G3, Shkbp1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_138676
Synonyms	B930062H15Rik; Sb1
Summary	Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation (PubMed:21830225).[UniProtKB/Swiss-Prot Function]

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