Mouse Rnf43 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rnf43
Locus ID	207742
Kit Components	GA212824G1, Rnf43 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212824G2, Rnf43 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212824G3, Rnf43 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_172448, NM_001363437
Synonyms	4732452J19Rik
Summary	E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity).[UniProtKB/Swiss-Prot Function]

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