Mouse Gsap activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Gsap
Locus ID	212167
Kit Components	GA213068G1, Gsap gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213068G2, Gsap gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213068G3, Gsap gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_175437, NM_001359876, NM_001359877, NR_153365, NR_153366
Synonyms	A530088I07Rik; Pion
Summary	Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.[UniProtKB/Swiss-Prot Function]

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