Mouse Fbxl21 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Fbxl21
Locus ID	213311
Kit Components	GA213139G1, Fbxl21 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213139G2, Fbxl21 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213139G3, Fbxl21 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001346732, NM_178674, NM_001359807
Synonyms	D630045D17Rik; FBL3B; FBXL3B; Psttm
Summary	Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities.[UniProtKB/Swiss-Prot Function]

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