Mouse Adgrg6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Adgrg6
Locus ID	215798
Kit Components	GA213301G1, Adgrg6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213301G2, Adgrg6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213301G3, Adgrg6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001002268
Synonyms	1190004A11Rik; AI449247; AW045736; DREG; Gm222; Gpr126
Summary	G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons these functions are mediated via G-protein-signaling pathways (PubMed:24227709, PubMed:21613327). Regulates also neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis (PubMed:27501152).[UniProtKB/Swiss-Prot Function]

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