Mouse Il31ra activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Il31ra
Locus ID	218624
Kit Components	GA213557G1, Il31ra gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213557G2, Il31ra gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213557G3, Il31ra gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_139299
Synonyms	CRL3; GLM-R; Glmr; GPL; NR10
Summary	Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (PubMed:24373353). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (PubMed:17379091).[UniProtKB/Swiss-Prot Function]

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