Mouse Fgd4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Fgd4
Locus ID	224014
Kit Components	GA213660G1, Fgd4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213660G2, Fgd4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213660G3, Fgd4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001301817, NM_001301818, NM_139232, NM_139233, NM_139234
Synonyms	9030023J02Rik; 9330209B17Rik; Frabp; ZFYVE6
Summary	This gene is a member of the FYVE, RhoGEF and PH domain containing (FGD) family. The encoded protein is a Cdc42-specific guanine nucleotide exchange factor (GEF) that plays an essential role in regulating the actin cytoskeleton and cell morphology. Disruption of the gene in mouse causes abnormal nerve development and dysmyelination. Mutations in a similar gene in human can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

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