Mouse Scaf4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Scaf4
Locus ID	224432
Kit Components	GA213691G1, Scaf4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213691G2, Scaf4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213691G3, Scaf4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001346799, NM_178923, NM_001358402
Synonyms	AA517739; Sfrs15; Sra4; Srsf15
Summary	Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough.[UniProtKB/Swiss-Prot Function]

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