Mouse Cyp2c23 activation kit by CRISPRa
CAT#: GA213829
Cyp2c23 CRISPRa kit - CRISPR gene activation of mouse cytochrome P450, family 2, subfamily c, polypeptide 23
CNY 12255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Cyp2c23 |
Locus ID | 226143 |
Kit Components | GA213829G1, Cyp2c23 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213829G2, Cyp2c23 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213829G3, Cyp2c23 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Reference Data | |
RefSeq | NM_001001446, NM_001167905 |
Synonyms | AW107714; b2b386Clo; BC034834 |
Summary | A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling (PubMed:15084647). Catalyzes preferentially the epoxidation of double bonds of PUFAs (PubMed:15084647). Converts arachidonoic acid primarily to stereospecific products (8R,9S)-epoxyeicosatrienoate (EET) and (11R,12S)-EET (PubMed:15084647). Via EETs may inhibit the epithelial sodium channels in nephron segments, leading to increased sodium excretion and stable systemic blood pressure (PubMed:24966089, PubMed:24368771). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:15084647).[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN504119 | Cyp2c44 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
CNY 8680.00 |
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