Mouse Cyp2c23 activation kit by CRISPRa

CAT#: GA213829

Cyp2c23 CRISPRa kit - CRISPR gene activation of mouse cytochrome P450, family 2, subfamily c, polypeptide 23



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CNY 12255.00


货期*
4周

规格
    • 1 kit

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Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol Cyp2c23
Locus ID 226143
Kit Components

GA213829G1, Cyp2c23 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA213829G2, Cyp2c23 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA213829G3, Cyp2c23 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Reference Data
RefSeq NM_001001446, NM_001167905
Synonyms AW107714; b2b386Clo; BC034834
Summary A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling (PubMed:15084647). Catalyzes preferentially the epoxidation of double bonds of PUFAs (PubMed:15084647). Converts arachidonoic acid primarily to stereospecific products (8R,9S)-epoxyeicosatrienoate (EET) and (11R,12S)-EET (PubMed:15084647). Via EETs may inhibit the epithelial sodium channels in nephron segments, leading to increased sodium excretion and stable systemic blood pressure (PubMed:24966089, PubMed:24368771). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:15084647).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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