Mouse Slf2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Slf2
Locus ID	226151
Kit Components	GA213831G1, Slf2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213831G2, Slf2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213831G3, Slf2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001081225, NM_172638
Synonyms	3632432H19; 6030443O07Rik; AU014917; Slf2
Summary	Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions.[UniProtKB/Swiss-Prot Function]

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