Mouse Dennd1a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dennd1a
Locus ID	227801
Kit Components	GA213978G1, Dennd1a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213978G2, Dennd1a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213978G3, Dennd1a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_146122, NM_001362973, NM_001362977, NM_001362978
Synonyms	6030446I19Rik; connecdenn
Summary	Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:17182770, PubMed:20159556). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (PubMed:20159556).[UniProtKB/Swiss-Prot Function]

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