Mouse Tlk1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tlk1
Locus ID	228012
Kit Components	GA213986G1, Tlk1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213986G2, Tlk1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213986G3, Tlk1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_172664, NM_001362963
Synonyms	4930545J15Rik
Summary	Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly (By similarity). Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10' (By similarity).[UniProtKB/Swiss-Prot Function]

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