Mouse Madd activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Madd
Locus ID	228355
Kit Components	GA213997G1, Madd gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213997G2, Madd gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213997G3, Madd gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001177719, NM_001177720, NM_001177721, NM_001177722, NM_001177723, NM_001177724, NM_001177725, NM_001177726, NM_001177727, NM_001177728, NM_001177729, NM_145527
Synonyms	9630059K23Rik; IG20
Summary	Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis).[UniProtKB/Swiss-Prot Function]

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