Mouse Rspo4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rspo4
Locus ID	228770
Kit Components	GA214026G1, Rspo4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214026G2, Rspo4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214026G3, Rspo4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001040689, NM_175468
Synonyms	A730099F22; A930029K19Rik
Summary	Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.[UniProtKB/Swiss-Prot Function]

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