Mouse Lin54 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Lin54
Locus ID	231506
Kit Components	GA214261G1, Lin54 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214261G2, Lin54 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214261G3, Lin54 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001115010, NM_001346583, NM_172714, NM_001359914
Synonyms	AI461788
Summary	Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA.[UniProtKB/Swiss-Prot Function]

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