Mouse Kmt5c activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Kmt5c
Locus ID	232811
Kit Components	GA214382G1, Kmt5c gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214382G2, Kmt5c gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214382G3, Kmt5c gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001115018, NM_146177, NM_001358044
Synonyms	BC024816; Suv4-20h2; Suv420h2
Summary	Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).[UniProtKB/Swiss-Prot Function]

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