Mouse Tmtc3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tmtc3
Locus ID	237500
Kit Components	GA214730G1, Tmtc3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA214730G2, Tmtc3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA214730G3, Tmtc3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001033332, NM_001110013
Synonyms	9130014E20Rik; B130008E12Rik; mSmile
Summary	Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response.[UniProtKB/Swiss-Prot Function]

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